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KMID : 0043320140370050600
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Archives of Pharmacal Research
2014 Volume.37 No. 5 p.600 ~ p.605
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A new phenylethanoid glycoside with antioxidant and anti-HBV activity from Tarphochlamys affinis
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Zhou Xian Li
Wen Qing Wei
Lin Xing
Zhang Shi Jun
Li Ying Xin
Guo You Jia
Huang Ren Bin
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Abstract
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A new phenylethanoid glycoside, named taraffinisoside A (1), together with five known glycosides were isolated from the stems and leaves of Tarphochlamys affinis. The structure of taraffinisoside A was identified on the basis of detailed spectral analysis. Compounds 1?4 and 6 showed potent antioxidant activities with IC50 values of 10.36, 19.73, 43.95, 15.30 and 46.04 μM by 1,1-diphenyl-2-picryhydrazyl radical-scavenging assay. Compounds 1, 2 and 4 showed anti-HBV activities, with IC50 values of 0.50, 0.72 and 0.26 mM for HBsAg and 0.93, 0.42 and 0.07 mM for HBeAg, respectively.
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KEYWORD
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Tarphochlamys affinis, Phenylethanoid, Glycoside, Antioxidant activity, Anti-HBV activity
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